Methyl Factors (formerly Methyl Protect) 2 fl oz./ 59 ml

Methyl Factors provides therapeutic doses of vitamins B6, B12, and folate in a highly absorbable liquid formula. These essential B vitamins support proper endogenous methylation activity as well as healthy production of red blood cells, neurotransmitters, hormones, and nucleic acids. The compound homocysteine occurs as a byproduct of the series of B12/B6/folate-dependent methylation reactions involved in methionine/cysteine metabolism. Elevated levels of homocysteine have been associated with cardiovascular risk through believed promotion of atherosclerotic plaque development and enhanced blood clotting activity. In clinical trials, supplementation with the involved B vitamins has been shown to reduce circulating homocysteine levels and therefore support cardiovascular health.

Folate (Folic Acid) is provided as a combination of 5-methyltetrahydrofolate (5-MeTHF) and 5-formyltetrahydrofolate (calcium folinate). Although, folic acid is the most oxidized and stable form of folate and is commonly used as a dietary supplement, it is not the metabolically active form. Folic acid must be reduced and methylated to 5-MeTHF to become the metabolically active form found in blood and utilized by tissues. Research has shown a subset of individuals with MTHFR polymorphism do not efficiently convert folic acid to the active 5-MeTHF due to genetic enzyme deficiencies. It is important to remember that 5-MeTHF is A form of the methyl group donor required for the conversion of homocysteine to methionine, which is catalyzed by vitamin B12-dependent methionine synthase. Without sufficient 5-MeTHF, regeneration of methionine cannot occur, resulting in possible homocystenemia.